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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

Figure 4

The effect of HA-1077 on angiotensin-II induced contraction in aortic strips isolated from normoglycemic (group N), in vivo losartan treated normoglycemic (group NL), diabetic (group D) and in vivo losartan treated diabetic rats (group DL). Cumulative concentration-response curves of angiotensin-II (bolus) were performed on 100 nM phenylephrine (Phe) pre-contracted thoracic aortic strips stretched to 0.7 g resting tension with an endothelial-intact layer and pre-incubated with 10 μM HA-1077. The contraction obtained with 100 nM Phe was set as 100%. The insert shows the decrease in contraction (reported as mg/mg of tissue w.w., absolute value) obtained with HA-1077 on angiotensin-II-induced (1 μM) contracture. Values are the mean ± SEM of 4 experiments. ***P < 0.001 vs. all other groups; §§§P < 0.01 vs. N and D groups.

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Cardiovascular Diabetology

ISSN: 1475-2840