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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats

Figure 3

The effect of irbesartan and irbesartan plus PD123319 on angiotensin-II induced contraction in aortic strips isolated from normoglycemic (N), in vivo losartan treated normoglycemic (NL), diabetic (D) and in vivo losartan treated diabetic rats (DL). Cumulative concentration-response curves of angiotensin-II (bolus) were performed on 100 nM phenylephrine (Phe) pre-contracted thoracic aortic strips stretched at 0.7 g resting tension with an endothelial-intact layer and pre-incubated with 1 μM irbesartan or 1 μM irbesartan plus 1 μM PD123319. The contraction obtained with 100 nM Phe was set as 100%. Values are the mean ± SEM of 4 experiments. Concentration-response curves of angiotensin II were significantly (at least P < 0.05) reduced by irbesartan in aortas from all groups. At condition of irbesartan plus PD123319, angiotensin-II contraction was reduced further (at least P < 0.05). For the clarity, significant level marks are omitted from the figure.

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Cardiovascular Diabetology

ISSN: 1475-2840