Figure 3

Effects of m7E3 on proliferative responses of HEK cells. β₃ integrin-deficient HEK cells were transfected with an empty vector or pcDNA-1neo constructs encoding full-length β₃ integrin subunits. The cells were grown in serum-containing media (0.5% or 5%) or insulin (1 μmol/L) for five days (A). In panel B, insulin (1 μmol/L) was added ± m7E3 or 10E5 (20 μg/ml). Cell number assays were performed 5 days later. [* – p < 0.05 vs 0.5% FBS in A and * – p < 0.05 vs insulin or insulin + 10E5 in B].