Figure 6

Steps Involved in Glucose Utilization. Schematic representation of the three steps involved in glucose utilization. In most cases, glucose transport is believed to be the rate limiting step. However, in conditions of hyperinsulinemia like that seen in high-salt-fed Dahl S rats, the rate limiting step may switch to phosphorylation [63,64]. Pertubations in any of these steps might precipitate the high salt-induced insulin resistance in Dahl S rats.