Figure 4
From: Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
Structural Determinants of Insulin Receptor Substrates. IRS-1 and -2 are considerably similar in their general architecture [23,24,38]. They are composed of an NH2-terminal, pleckstrin homology (PH) domain that binds to membrane phospholipids, a phosphotyrosine binding (PTB) domain located just upstream the PH domain and is involved in the recognition of the asparagines-proline-glutamic acid-phosphotyrosine (NPEpY) sequence located in the juxtamembrane region of the insulin receptor β subunit, phosphoserine binding domain (PSB), and a less conserved COOH-terminal portion with multiple tyrosine phosphorylation motifs that can bind to specific SH2 domain-containing proteins.