Effect of the addition of rosiglitazone to metformin or sulfonylureas versus metformin/sulfonylurea combination therapy on ambulatory blood pressure in people with type 2 diabetes: A randomized controlled trial (the RECORD study)

Table 4 Contrast between day- and night-time effects of rosiglitazone on ambulatory BP at 12 months

	Background metformin	Background sulfonylurea
	rosiglitazone vs sulfonylurea (difference (95% CI), p-value)	rosiglitazone vs metformin (difference (95% CI), p-value)
Systolic BP (mmHg)
24-hour	-2.7 (-4.9, -0.5), 0.016	-2.5 (-4.8, -0.2), 0.031
Day-time	-3.3 (-5.6, -1.0), 0.004	-1.6 (-3.9, 0.9), NS
Night-time	-1.5 (-3.9, 1.0), NS	-4.0 (-6.6, -1.3), 0.004
Diastolic BP (mmHg)
24-hour	-2.1 (-3.4, -0.7), 0.003	-3.1 (-4.5, -1.8), < 0.001
Day-time	-2.5 (-3.9, -1.0), 0.001	-2.5 (-3.9, -1.0), 0.001
Night-time	-1.3 (-2.9, 0.3), NS	-4.0 (-5.7, -2.4), < 0.001

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