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Table 1 Patient characteristics and associations of sRAGE and esRAGE with different variables in 110 patients with type 2 diabetes

From: Soluble RAGE but not endogenous secretory RAGE is associated with albuminuria in patients with type 2 diabetes

   sRAGE# esRAGE#
Characteristics univariate (R) multivariate (β) univariate (R) multivariate (β)
Age (years) 59 ± 7 0.22* - 0.23* 0.24**
Gender (f/m) 24/86 - 0.21* - -
Diabetes duration (years) 13 ± 8 0.11 - 0.11 -
BMI (kg/m2) 33 ± 6 0.04 - -0.04 -
HbA1c (%) 7.4 ± 1.2 -0.02 - 0.05 -
Fasting glucose (mmol/l) 8.2 ± 3.0 0.05 - 0.05 -
Glomerular filtration rate (ml/min) 128 ± 50 -0.15 - -0.14 -
mean 24 h systolic BP (mmHg) 141 ± 16 0.02 - -0.06 -
mean 24 h diastolic BP (mmHg) 80 ± 8 -0.14 - -1.8 -
24 h Albumin excretion (mg)# 170 ± 406 0.18* 0.22* 0.10 -
Macrovascular Complications (%) 33     
Retinopathy (%) 27     
Polyneuropathy (%) 52     
Insulin therapy (%) 64     
ACE-Inhibitors/AT-R antagonists (%) 88     
  1. Data is given as mean ± SD. R = Spearman correlation coefficient. β = standardized coefficient as given by stepwise multivariate regression analysis. # = variables were not normally distributed and log-transformed for multivariate analysis. * p ≤ 0.05, ** p ≤ 0.01