Table 3 Results of association analyses between each genotype of candidate genes and coronary artery calcium score (CACS).
a. | |||||
Gene (SNPs) | Genotype | No. of patients | CACS (HU) | p value | |
CAPN10 (A/G-iSNP43) | G/G | 84 (92.3%) | 362 ± 735 | 0.456 | |
G/A | 7 (7.7%) | 153 ± 150 | |||
ADRB3 (Try64Arg) | Try/Try | 55 (61.8%) | 377 ± 776 | 0.621 | |
Arg/Arg & Arg/Try | 34 (38.2%) | 301 ± 605 | |||
PPARγ (Pro12Ala) | Pro/Pro | 85 (93.4%) | 335 ± 686 | 0.580 | |
Ala/Pro & Ala/Ala | 6 (6.6%) | 502 ± 1049 | |||
FATP4 (Gly209Ser) | Gly/Gly | 48 (52.7%) | 346 ± 797 | 0.991 | |
Ser/Ser & Ser/Gly | 43 (47.3%) | 346 ± 605 | |||
b. | |||||
Gene (SNPs) | Genotype | No. of patients | CACS (HU) | p value | |
GPx-1 (Pro197Leu) | Pro/Pro | 71 (78.0%) | 245 ± 399 | 0.006 * | |
Pro/Leu | 20 (22.0%) | 744 ± 1291 | |||
Catalase (SNP-89) | T/T | 25 (27.5%) | 319 ± 573 | 0.821 | |
A/T & A/A | 66 (72.5%) | 357 ± 758 | |||
Mn-SOD (Ala16Val) | Val/Val | 49 (55.7%) | 293 ± 669 | 0.440 | |
Val/Ala & Ala/Ala | 39 (44.3%) | 408 ± 756 | |||
Cu/Zn-SOD (intron 3) | C/C | 34 (37.4%) | 370 ± 788 | 0.805 | |
C/A & A/A | 57 (62.6%) | 332 ± 664 | |||
NADPH oxidase (exon 4) | C/C | 79 (86.8%) | 311 ± 724 | 0.224 | |
T/T & T/C | 12 (13.2%) | 579 ± 567 |