Skip to main content

Advertisement

Table 3 Results of association analyses between each genotype of candidate genes and coronary artery calcium score (CACS).

From: Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography

a.      
  Gene (SNPs) Genotype No. of patients CACS (HU) p value
  CAPN10 (A/G-iSNP43) G/G 84 (92.3%) 362 ± 735 0.456
   G/A 7 (7.7%) 153 ± 150  
  ADRB3 (Try64Arg) Try/Try 55 (61.8%) 377 ± 776 0.621
   Arg/Arg & Arg/Try 34 (38.2%) 301 ± 605  
  PPARγ (Pro12Ala) Pro/Pro 85 (93.4%) 335 ± 686 0.580
   Ala/Pro & Ala/Ala 6 (6.6%) 502 ± 1049  
  FATP4 (Gly209Ser) Gly/Gly 48 (52.7%) 346 ± 797 0.991
   Ser/Ser & Ser/Gly 43 (47.3%) 346 ± 605  
b.      
  Gene (SNPs) Genotype No. of patients CACS (HU) p value
  GPx-1 (Pro197Leu) Pro/Pro 71 (78.0%) 245 ± 399 0.006 *
   Pro/Leu 20 (22.0%) 744 ± 1291  
  Catalase (SNP-89) T/T 25 (27.5%) 319 ± 573 0.821
   A/T & A/A 66 (72.5%) 357 ± 758  
  Mn-SOD (Ala16Val) Val/Val 49 (55.7%) 293 ± 669 0.440
   Val/Ala & Ala/Ala 39 (44.3%) 408 ± 756  
  Cu/Zn-SOD (intron 3) C/C 34 (37.4%) 370 ± 788 0.805
   C/A & A/A 57 (62.6%) 332 ± 664  
  NADPH oxidase (exon 4) C/C 79 (86.8%) 311 ± 724 0.224
   T/T & T/C 12 (13.2%) 579 ± 567  
  1. Difference of CACS according to each genotype of candidates genes. a) genes that are associated with onset of type 2 diabetes. b) genes that are related to the redox balance. Student t-test; * : p < 0.05.