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Archived Comments for: Serum leptin and its relation to anthropometric measures of obesity in pre-diabetic Saudis

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  1. Biophysical-Semeiotic Bedside Evaluation of Leptin.

    Sergio Stagnaro, Biophysical Semeiotics Rsearch Laboratory

    29 November 2007


    Leptin receptors are highly expressed in areas of the hypothalamus known to be important in regulating body weight, as well as in T lymphocytes and vascular endothelial cells (See Practical Applications in

    Such as physiological events represent the rationale of biophysical-semeiotic bedside evaluation of leptin concentrations, augmented in metabolic syndrome and often in advanced stages of pre-metabolic syndrome, classic and variant. Thus, the possibility of recognizing, for the first time clinically, leptin increase constitutes a diagnostic tool of essential importance, applicable on very large scale.

    Recent studies with obese and non-obese humans demonstrated a strong positive correlation of serum leptin concentrations with percentage of body fat, and also that there was a higher concentration of ob mRNA in fat from obese compared to thin subjects. Genetically obese mices with inactivating mutations in the ob gene or the gene encoding the leptin receptor (db gene) have been known for many years and were instrumental in the initial cloning of the ob gene 2, 5, 6).

    It appears that as adipocytes increase in size due to accumulation of triglyceride, they synthesize more and more leptin. In essence, leptin provides the body with an index of nutritional status. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.

    Decreased hunger and food consumption, mediated at least in part by inhibition of neuropeptide Y synthesis. Neuropeptide Y is a very potent stimulator of feeding behavior.

    Increased energy expenditure, measured as increased oxygen consumption, higher body temperature and loss of adipose tissue mass.

    The mechanisms by which leptin exerts its effects on metabolism are largely unknown and are likely quite complex. In contrast to dieting, which results in loss of both fat and lean mass, treatment with leptin promotes lipolysis in adipose tissue, but has no apparent effect on lean tissue.

    Recent studies in obese and non-obese humans demonstrated positive correlation between serum leptin concetration and percentage of body adipose tissue and highest presence of ob-m-RNA in adipose tissue than that observed in lean individuals (7). These data were corroborated clinically by Biophysycal Semeiotics (8).


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    8) Stagnaro S. Pre-metabolic syndrome: the real initial stage of metabolic-syndrome, type 2 diabetes and arteroscleropathy. Cardiovascular Diabetology 2004, 3:1

    Competing interests

    None declared