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Table 1 Genes related to the insulin signaling cascade which are specifically modulated by OxLDL in comparison to mmLDL and vehicle in hyperinsulinemic hyperglycemic conditions.

From: Insulin and glucose play a role in foam cell formation and function

   Mean absolute intensity    
Description Locus Link Vehicle mmLDL OxLDL Fold change: OxLDL vs. Vehicle P: OxLDL vs. Vehicle P: OxLDL vs. mmLDL
Insulin receptor 3643 19.7 33.0 76.8 3.90 <0.004 <0.009
Insulin receptor substrate 2 (IRS2) 8660 193.0 199.0 471.1 2.44 <0.000001 <0.000001
Glucose-6-phosphate dehydrogenase 2539 1665.8 3410.6 3866.6 2.32 <0.000001 N.S.*
Insulin induced gene 1 (Insig-1) 3637 1485.7 1024.8 274.6 -5.41 <0.000001 <0.000001
Phosphoinositide-3-kinase. Catalytic; delta polypeptide (PIK3CD) 5293 1890.4 1427.2 984.2 -1.92 <0.000001 = 0.001
  1. *) N.S. – not statistically significant (p > 0.05).