Figure 4From: The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloadedFormation of age. The formation of AGE, as a result of chronic hyperglycemia, is complex and this figure demonstrates the steps and time frames involved in the formation of AGE and cross-linking of proteins. This complex process is reversible until the NH-R(n)'s are crosslinked.Back to article page