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Table 1 Tissue wound injury: a common link between two chronic diseases: OSTEOATHEROITIS and OSTEOARTHRITIS.

From: Vascular ossification – calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis – calcific uremic arteriolopathy: the emerging role of sodium thiosulfate

T Tissue wound healing: a recapitulation of embryologic genetic memory
I Injury – Inflammation: OSTEOATHEROITIS – OSTEOARTHRITIS
G Granulation tissue formation (angiogenesis)
E Endothelial cell activation, proliferation, migration: ANGIOGENESIS
R Remodeling of the AVW: initially positive outward remodeling and over time a chronically negative inward arterial remodeling (see Scar contracture). Repair. Restructure. Resolution: results, only if the chronic injurious stimuli and sensitizers are removed from the endothelial, intimal, and medial layers of the arterial vessel wall. The above 4 (R's): activate pleuripotent mesenchymal stem-cell pericytes and VSMCs to produce bone morphogenic proteins, which are also activated by (I): Injury and Inflammation with resulting inflammatory cytokines such as TNF alpha, IL-6 and decreased IL-10.
S Scar: contracture and negative remodeling resulting in stenosis. AVW stiffness even without ossification.