|T||Tissue wound healing: a recapitulation of embryologic genetic memory|
|I||Injury – Inflammation: OSTEOATHEROITIS – OSTEOARTHRITIS|
|G||Granulation tissue formation (angiogenesis)|
|E||Endothelial cell activation, proliferation, migration: ANGIOGENESIS|
Remodeling of the AVW: initially positive outward remodeling and over time a chronically negative inward arterial remodeling (see Scar contracture).|
Resolution: results, only if the chronic injurious stimuli and sensitizers are removed from the endothelial, intimal, and medial layers of the arterial vessel wall.
The above 4 (R's): activate pleuripotent mesenchymal stem-cell pericytes and VSMCs to produce bone morphogenic proteins, which are also activated by (I): Injury and Inflammation with resulting inflammatory cytokines such as TNF alpha, IL-6 and decreased IL-10.
Scar: contracture and negative remodeling resulting in stenosis.|
AVW stiffness even without ossification.