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Figure 9 | Cardiovascular Diabetology

Figure 9

From: Saturated free fatty acids and apoptosis in microvascular mesangial cells: palmitate activates pro-apoptotic signaling involving caspase 9 and mitochondrial release of endonuclease G

Figure 9

Oleate inhibits caspase 9 activation by palmitate. HMC were treated with palmitate (0.2 and 0.4 mM) or palmitate plus oleate (0.2 mM) for 24 and 48 h. Caspase 9 activity was then measured in HMC extracts adjusted for total protein. In some experiments the cells were treated with palmitate plus selective inhibitors of caspase 9 (C9I) or caspase 8 (C8I) at 40 μM. Data are mean ± SEM for n = 3 experiments in duplicate. **, P < 0.01, *, P < 0.05 versus control or palmitate plus oleate by ANOVA.

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