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Table 1 Characterization of the study population by AMI phenotype and the α2B-adrenoceptor insertion/deletion genotype.

From: The insertion/deletion variation in the α2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes

 

Phenotype

Genotype

 

AMI (n = 154)

No AMI (n = 154)

P

DD (n = 73)

ID (n = 132)

II (n = 103)

P

ID + II (n = 235)

P (vs. DD)

Age (years)

67.1 ± 0.8

66.9 ± 0.8

0.59

66.7 ± 1.0

67.0 ± 0.8

67.2 ± 1.0

0.35

67.1 ± 0.6

0.45

BMI (kg/m2)

28.0 ± 0.3

27.2 ± 0.3

0.038

28.1 ± 0.5

27.2 ± 0.4

27.9 ± 0.5

0.62

27.5 ± 0.3

0.43

Systolic BP (mmHg)

143 ± 1

145 ± 2

0.38

145 ± 2

144 ± 2

143 ± 2

0.81

144 ± 1

0.56

Diastolic BP (mmHg)

80.0 ± 0.9

82.1 ± 1.0

0.063

80.8 ± 1.1

81.7 ± 1.0

80.2 ± 1.2

0.62

81.1 ± 0.8

0.94

LDL cholesterol (mmol/l)

3.71 ± 0.09

3.76 ± 0.08

0.44

3.82 ± 0.11

3.70 ± 0.10

3.71 ± 0.10

0.84

3.71 ± 0.07

0.55

HDL cholesterol (mmol/l)

1.13 ± 0.02

1.27 ± 0.03

<0.001

1.19 ± 0.02

1.18 ± 0.03

1.19 ± 0.04

0.57

1.20 ± 0.03

0.32

Hypertension

127 (89%)

101 (70%)

<0.001

60 (53)

96 (97)

72 (78)

0.049

168 (175)

0.023

Smoking

76 (56%)

50 (38%)

<0.001

25 (29)

57 (55)

44 (42)

0.75

101 (97)

0.47

Diabetes

115 (75%)

90 (58%)

0.002

47 (49)

87 (88)

71 (69)

0.80

158 (156)

0.53

  1. Data for continuous variables are presented as mean ± SEM. Discrete variables are presented as number of subjects, and in parenthesis, either percentage of the group for which data are available (AMI phenotype) or the expected number by random distribution (α2B-adrenoceptor insertion/deletion genotype). Paired t test and McNemar's test were used to calculate the p value comparing the siblings discordant for history of AMI. Linear mixed models were used to calculate the p values in the comparison of the genotype groups.
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Cardiovascular Diabetology

ISSN: 1475-2840