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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Dopamine D4 receptors inhibit proliferation and migration of vascular smooth muscle cells induced by insulin via down-regulation of insulin receptor expression

Figure 5

Effect of PD168077 on neointimal formation after vascular injury in SD rats with hyperinsulinemia. Carotid balloon-injured rats were intraperitoneally injected with vehicle or PD168077 (6 mg/kg/day) for 14 days. Representative histologies (A-C) were shown above the bar graphs. A: sham operation control. B: balloon-injured carotid artery and vehicle injection. C: balloon-injured carotid artery and PD168077 injection. The bar graphs show the area of the intima to media ratio (I/M ratio, D) (n = 6, *P < 0.05 vs. sham group, #P < 0.05 vs. balloon-injured and vehicle group).

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Cardiovascular Diabetology

ISSN: 1475-2840