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Table 5 Multivariate adjusted hazards ratio of mortality according to different categories of HbA 1c level in people with different genotypes

From: PLA1A2 platelet polymorphism predicts mortality in prediabetic subjects of the population based KORA S4-Cohort

 

RR (95% CI)

Categories of HbA1c level

Genotype: A1A1

Genotype: AxA2

<5% (<31 mmol/mol)

0.85 (0.34, 2.09)

1.68 (0.51, 5.61)

5.1/5.2% (32/33 mmol/mol)

1.29 (0.66, 2.52)

0.77 (0.18, 3.27)

5.3% (34 mmol/mol)

1.03 (0.48, 2.21)

1.18 (0.31, 4.51)

5.4% (36 mmol/mol)

0.80 (0.36, 1.78)

1.34 (0.38, 4.72)

5.5% (37 mmol/mol)

1

1

5.6% (38 mmol/mol)

0.85 (0.42, 1.72)

0.51 (0.12, 2.18)

5.7% (39 mmol/mol)

1.23 (0.64, 2.39)

1.31 (0.43, 3.99)

5.8% (40 mmol/mol)

0.69 (0.29, 1.64)

1.62 (0.46, 5.69)

5.9/6.0% (41/42 mmol/mol)

0.99 (0.49, 1.99)

1.37 (0.44, 4.28)

>6.5% (>48 mmol/mol)

1.35 (0.73, 2.51)

2.97 (1.07, 8.24)

  1. The hazard ratios and 95% confidence interval are given for each decile of HbA1c level (≤5% (31 mmol/mol), 5.1% (32 mmol/mol)/5.2% (33 mmol/mol), 5.3% (34 mmol/mol), 5.4% (36 mmol/mol), 5.5% (37 mmol/mol), 5.6% (38 mmol/mol), 5.7% (39 mmol/mol), 5.8% (40 mmol/mol), 5.9% (41 mmol/mol)/6.0% (42 mmol/mol), >6.5% (48 mmol/mol)), taking HbA1c = 5.5% (37 mmol/mol) as the reference. The model was adjusted for blood pressure (diastolic and systolic), cholesterol (total, HDL, LDL), smoking status (categorized: non-smoker, former smoker, current smoker), alcohol intake (categorized: ≥20 g/day for women; ≥40 g/day for men), physical activity (categorized: >1 h per week), platelet mass, mean plate volume and platelet count.
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Cardiovascular Diabetology

ISSN: 1475-2840