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Table 3 Fetal gene program activation as a measure of cardiomycoyte hypertrophy

From: High glucose induces Smad activation via the transcriptional coregulator p300 and contributes to cardiac fibrosis and hypertrophy

 

Control

Diabetes

Diabetes + Curcumin

ANF

1.02 ± 0.04

1.6 ± 0.28a

0.93 ± 0.08b

SERCA

1.02 ± 0.10

0.63 ± 0.08a

1.72 ± 0.13b,c

α MHC

1.03 ± 0.07

0.3 ± 0.06a

0.2 ± 0.02a

β MHC

1.01 ± 0.10

2.2 ± 0.31a

5.12 ± 0.36b,c

  1. ANF is atrial natriuretic factor; SERCA is sarcoplasmic reticulum Ca2+-ATPase; α MHC is alpha myosin heavy chain; β MHC is β myosin heavy chain. Units are fold changes compared to control relative to housekeeping gene RPL32a. ap < 0.05 compared with control, bp < 0.05 compared with diabetes group, cp < 0.01 compared with control.
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Cardiovascular Diabetology

ISSN: 1475-2840