Table 1 Animal characteristics of TGR(mRen-2)27 rats

Plasma glucose (mmol/l)

6.5 ± 0.4

30 ± 0.7^a

29 ± 0.95^a

Body weight (g)

307 ± 25

170 ± 12^a

171 ± 13^a

Tibial length (mm)

37 ± 0.3

28 ± 0.4^a

31 ± 0.5^a,b

Heart weight (g)

1.2 ± 0.06

0.6 ± 0.04^a

0.51 ± 0.05^a

Heart weight:body weight (mg/g)

4.2 ± 0.2

3.2 ± 0.12^a

2.37 ± 0.07^a,b

HW:TL (g/mm)

3.4 ± 0.16

2.2 ± 0.17^a

1.76 ± 0.1^a,b

LV (g)

0.91 ± 0.03

0.52 ± 0.04^a

0.41 ± 0.03^a,b

LV:body weight (mg/g)

3.3 ± 0.15

2.8 ± 0.11^a

2.4 ± 0.07^a,b

LV:TL (g/mm)

2.47 ± 0.10

1.9 ± 0.1^a

1.32 ± 0.1^a,b

Lung weight (g)

1.2 ± 0.7

1.07 ± 0.04^a

0.84 ± 0.07^a,b

Lung weight:body weight (mg/g)

0.41 ± 0.01

0.54 ± 0.03^a

0.51 ± 0.04^a

LW:TL (g/mm)

3 ± 0.2

3.25 ± 0.06

2.9 ± 0.08