Figure 6
From: Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway
Cardiomyocyte viability after the Inhibition of RAGE and PI3K/Akt/mTOR pathway on cell viability. Compared to control cells, AGEs treatment dramatically reduced the cell viability, but rapamycin along did not significantly change the cell viability. Inhibition of RAGE by its antibody can rescue cell viability induced by AGEs treatment; however, this beneficial effect was abolished by additional rapamycin treatment.