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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Advanced glycation endproducts trigger autophagy in cadiomyocyte Via RAGE/PI3K/AKT/mTOR pathway

Figure 4

The effect of AGEs treatment on RAGE ,PI3K/Akt/mTOR pathway in cultured cardiomyocytes. AGEs treatment stimulated the RAGE expression, however, inhibited the PI3K/Akt/mTOR pathway in cultured cardiomyocytes compared to controls. RAGE antibody pretreatment re-activated the PI3K/Akt/mTOR pathway and reduced Beclin1 and LC3-II. Interestingly, the addition mTOR inhibitor rapamycin increased the Beclin1 and LC3 expression again compared to cell receiving RAGE antibody pretreatment.

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