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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway

Figure 5

Effect of OCN on PI3K, Akt and eNOS phosphorylation in descending thoracic aortic strips of ApoE-KO mice. (A) Representative Western blot to show the expression of PI3K, phosphorylated PI3K, Akt, phosphorylated Akt, eNOS, phosphorylated eNOS. (B) Effect of OCN on PI3K phosphorylation. (C) Effect of OCN on Akt phosphorylation. (D) Effect of OCN on eNOS phosphorylation. Values represent mean ± SEM, 6 to 8 mice per group were analyzed. *P < 0.05, **P < 0.01, OCN-treated mice vs. vehicle-treated mice in chow diet group; #P < 0.05, ##P < 0.01, OCN-treated mice vs. vehicle-treated mice in HFD group. HF, high fat diet; CD, chow diet; OCN, osteocalcin.

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Cardiovascular Diabetology

ISSN: 1475-2840