Figure 4

Effect of OCN on EDR in descending thoracic aortic strips of ApoE-KO mice. (A–B) ACh-mediated EDR. (C) Maximal relaxation values. (D) ACh-induced EDR in the presence of L-NAME. (E) Endothelium-independent relaxations to SNP. Values represent mean ± SEM, 6 to 8 mice per group were analyzed. **P < 0.01 vehicle-treated mice fed with HFD vs. vehicle-treated mice fed with chow diet; ^#P < 0.05, ^##P < 0.01 OCN-treated mice vs. vehicle-treated mice in HFD group. HF, high fat diet; CD, chow diet; EDR, endothelium-dependent relaxation; OCN, osteocalcin.