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Figure 5 | Cardiovascular Diabetology

Figure 5

From: Exenatide induces aortic vasodilation increasing hydrogen sulphide, carbon monoxide and nitric oxide production

Figure 5

Concentration-relaxation curves showing the possible effector molecules of the exenatide induced vasodilation. Blocking cAMP-dependent protein kinase A (PKA) with 5 μM H89 hydrochloride (A). Inhibiton of soluble guanylyl cyclase with 3 μM 1H- (1,2,4) (ODQ) (B). 23.9, 71.7, 310, 788, 1980, 3170 nanomoles of exenatide were used to relax the vessels (n = 5 of each experiment), *P < 0.01 compared to the relaxation caused by exenatide only (at respective concentration of exenatide)

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Cardiovascular Diabetology

ISSN: 1475-2840