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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression

Figure 3

Effects of ribaroxaban on MCP-1 (A) and ICAM-1 (B) gene expression in HUVECs. HUVECs were pre-incubated with or without the indicated concentrations of ribaroxaban for 30 min and treated with 100 μg/ml AGE-BSA, 100 μg/ml non-glycated BSA or 3% citrated human plasma for 4 hr. Then total RNAs were transcribed and amplified by real-time PCR. Data were normalized by the intensity of 18S mRNA-derived signals and then related to the value obtained with BSA alone. N = 5 per group. * **, p < 0.01 compared to the value with BSA + 3% human plasma alone. #, p < 0.05 compared to the value with AGEs + 3% human plasma alone.

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Cardiovascular Diabetology

ISSN: 1475-2840