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Table 2 Independent* relation of any CVD, any coronary event, AMI, any cerebrovascular event, stroke, any peripheral event, ulcer/gangrene, and non-advanced and advanced DR with eGFR and albuminuria categories grouped into AKDN risk category 1 and the corresponding KDIGO risk category moderate

From: Distribution of cardiovascular disease and retinopathy in patients with type 2 diabetes according to different classification systems for chronic kidney disease: a cross-sectional analysis of the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study

eGFR and albuminuria category

G1-A2

G2-A2

G3a-A1

Complication

OR

OR (95 % CI)

P

OR (95 % CI)

P

Any CVD

1.0

1.273 (1.038-1.562)

0.020

1.595 (1.264-2.012)

<0.0001

Any coronary event

1.0

1.293 (1.011 1.653)

0.040

1.883 (1.431 2.477)

<0.0001

AMI

1.0

1.294 (0.974-1.718)

0.075

1.907 (1.390-2.614)

<0.0001

Any cerebrovascular event

1.0

1.483 (1.080-2.036)

0.015

1.641 (1.147-2.349)

0.007

Stroke

1.0

1.708 (1.048-2.783)

0.032

1.587 (0.916-2.748)

0.099

Any peripheral event

1.0

1.409 (0.988 2.009)

0.058

2.005 (1.359 2.959)

<0.0001

Ulcer/gangrene

–

–

–

–

–

Non-advanced DR

1.0

0.994 (0.779-1.267)

0.961

0.771 (0.584 1.017)

0.065

Advanced DR

1.0

1.020 (0.784-1.328)

0.883

0.647 (0.474 0.884)

0.006

  1. *Confounders: age, gender, smoking habits, diabetes duration, HbA1c, anti-hyperglycemic treatment, triglycerides, HDL cholesterol, dyslipidemia, and hypertension.
  2. CVD, cardiovascular disease; AMI, acute myocardial infarction; DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; KDIGO, kidney disease: improving global outcomes; OR, odd ratio; CI, confidence interval.
  3. G1-A2: eGFR ≥90 ml/min/1.73 m2 with microalbuminuria (reference category); G2-A2: eGFR 60-89 ml/min/1.73 m2 with microalbuminuria; G3a-A1: eGFR 45-59 ml/min/1.73 m2 with normoalbuminuria.
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Cardiovascular Diabetology

ISSN: 1475-2840