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Table 2 Independent* relation of any CVD, any coronary event, AMI, any cerebrovascular event, stroke, any peripheral event, ulcer/gangrene, and non-advanced and advanced DR with eGFR and albuminuria categories grouped into AKDN risk category 1 and the corresponding KDIGO risk category moderate

From: Distribution of cardiovascular disease and retinopathy in patients with type 2 diabetes according to different classification systems for chronic kidney disease: a cross-sectional analysis of the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study

eGFR and albuminuria category G1-A2 G2-A2 G3a-A1
Complication OR OR (95 % CI) P OR (95 % CI) P
Any CVD 1.0 1.273 (1.038-1.562) 0.020 1.595 (1.264-2.012) <0.0001
Any coronary event 1.0 1.293 (1.011 1.653) 0.040 1.883 (1.431 2.477) <0.0001
AMI 1.0 1.294 (0.974-1.718) 0.075 1.907 (1.390-2.614) <0.0001
Any cerebrovascular event 1.0 1.483 (1.080-2.036) 0.015 1.641 (1.147-2.349) 0.007
Stroke 1.0 1.708 (1.048-2.783) 0.032 1.587 (0.916-2.748) 0.099
Any peripheral event 1.0 1.409 (0.988 2.009) 0.058 2.005 (1.359 2.959) <0.0001
Ulcer/gangrene
Non-advanced DR 1.0 0.994 (0.779-1.267) 0.961 0.771 (0.584 1.017) 0.065
Advanced DR 1.0 1.020 (0.784-1.328) 0.883 0.647 (0.474 0.884) 0.006
  1. *Confounders: age, gender, smoking habits, diabetes duration, HbA1c, anti-hyperglycemic treatment, triglycerides, HDL cholesterol, dyslipidemia, and hypertension.
  2. CVD, cardiovascular disease; AMI, acute myocardial infarction; DR, diabetic retinopathy; eGFR, estimated glomerular filtration rate; KDIGO, kidney disease: improving global outcomes; OR, odd ratio; CI, confidence interval.
  3. G1-A2: eGFR ≥90 ml/min/1.73 m2 with microalbuminuria (reference category); G2-A2: eGFR 60-89 ml/min/1.73 m2 with microalbuminuria; G3a-A1: eGFR 45-59 ml/min/1.73 m2 with normoalbuminuria.