Flow-mediated remodeling after treatment with ALT-711: Changes in diameter (A,B) in response to stepwise increases in pressure in HF and NF mesenteric resistance arteries isolated from lean Zucker (LZ, A) and diabetic fatty Zucker rats (ZDF, B) treated with ALT-711. Concentration-response curves to acetylcholine were performed in NF (C) and HF (D) arteries in the presence or absence of L-NAME (100 μmol/L). Emax for acetylcholine-mediated relaxation (E) and the inhibitory effect of L-NAME on acetylcholine-mediated relaxation (F) were calculated from the curves shown in C and D. Mean ± SEM is presented (n = 10 per group). *P < 0.05, HF arteries compared to NF arteries. #P < 0.05, ZDF compared to LZ.