| | C | HF- | HF+ |
|---|
Heart rate | 288 ± 29 | 248 ± 20 | 295 ± 20 |
LVDP | 82 ± 10a | 67 ± 2a,b | 56 ± 7b |
RPP | 22.9 ± 1.5a | 16.8 ± 1.7b | 16.4 ± 1.7b |
Coronary flow | 42.9 ± 7.5 | 40.2 ± 6.7 | 42.9 ± 13.7 |
CP before U46619 | 62.8 ± 6.4 | 67.5 ± 5.9 | 68.4 ± 3.8 |
CP after U46619 | 94.0 ± 3.9 | 106.0 ± 8.5 | 120.4 ± 7.7 |
- The number of experiments was 6 per group. The heart rate, pressures (left ventricular developed pressure or LVDP, coronary pressure or CP before and after U46619 infusion), rate pressure product (RPP) and coronary flow were expressed in beats/min, mmHg, mHg/min and ml/min/g of dry weight. C: control group; HF-: high fat-fed animal without weight gain compared to the control group; HF+: high fat-fed animals with weight gain compared to the control group; a, b: two means located on a same line without a common letter are significantly different.
