Figure 1
From: Impaired dopamine D1 receptor-mediated vasorelaxation of mesenteric arteries in obese Zucker rats
Relaxation of phenylephrine (PHE)-preconstricted rat mesenteric arterial rings in response to fenoldopam and sodium nitroprusside (SNP). Rat mesenteric arterial rings from obese and lean Zucker rats with (E+) (A) or without (E-) endothelium (B) were preconstricted with PHE (10-5M) and then treated with varying concentrations of fenoldopam (Fen, 10-9-10-5M) (*P < 0.01 vs. obese rats, n = 8). (C): D1-like receptor specificity of fenoldopam-induced vasorelaxation in rat mesenteric arterial rings. Rat mesenteric arterial rings from lean Zucker rats were preconstricted with PHE, and then incubated with fenoldopam (Fen, 10-6M) and/or SCH23390 (SCH, 10-7M) (*P < 0.01 vs. Fen, n = 6). (D): Rat mesenteric arterial rings from obese and lean Zucker rats with endothelium (E+) were preconstricted with PHE (10-5M) and then treated with varying concentrations of SNP (10-10-10-4M) (P = NS lean vs obese, n = 5).