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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK

Figure 4

Oxidative stress in 60-week old liver-specific gck knockout mice. Serum and myocardium SOD activity (A and B), MDA levels (C and D), and relative levels of mRNA for Cyba (E) and Cybb (F) in the myocardial are shown for wild-type (gckw/w) and gck knockout (gckw/–) mice as well as knockout mice treated with insulin or rosiglitazone for 4 weeks. mRNA levels were determined by real-time PCR and corrected with beta actin as an internal standard. n = 6 for all samples. Asterisk (*) refers to statistical significance (P < 0.05) in comparisons with gckw/– mice, while # refers to comparisons with gckw/w mice.

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Cardiovascular Diabetology

ISSN: 1475-2840