Figure 1
From: An accelerated mouse model for atherosclerosis and adipose tissue inflammation
Sucrose-enriched high-fat diet induces earlier insulin resistance in obese LDLR-/-mice. LDLR-/- mice were placed on LF control or two different high-fat diets both containing 0.15% cholesterol with (HFSC) or without sucrose enrichment (HFC). ApoE-/- mice were fed HFSC. Mean body weight after dietary treatment up to 20 weeks (A). Fasting plasma insulin and HOMA-IR was determined after treatment with indicated diets for 12 weeks (B and C; n = 8 animals per group except LF-fed LDLR-/- mice with n = 6). Glucose tolerance test was performed by intraperitoneal injection of 0.75 g 20% glucose/kg body weight after 12 weeks of feeding (n = 8 animals per group) (D). Fasting plasma insulin (E), HOMA-IR (F) and glucose tolerance (G) after dietary treatment for 20 weeks (n = 5–6 animals per group). For statistical analysis LDLR-/- mice fed HFSC or LF were compared with HFC-fed LDLR-/- mice. In addititon, LDLR-/- and ApoE-/- mice both fed HFSC were compared. All data represent mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001.