Cardiovascular Diabetology

Table 3 Multivariate analyses of the determinants for FMD and NMD in subjects with type 2 diabetes

From: Leptin is associated with vascular endothelial function in overweight patients with type 2 diabetes

	FMD						NMD
	All subjects		Lean		Overweight		All subjects		Lean		Overweight
	β	p	β	p	β	p	β	p	β	p	β	p
Age (years)	−0.178	0.081	−0.058	0.692	−0.246	0.096	−0.453	<0.001	−0.149	0.227	−0.724	<0.001
Sex (male = 1)	−0.014	0.917	−0.195	0.346	0.167	0.379	0.116	0.310	0.214	0.217	0.028	0.863
BMI (kg/m²)	0.035	0.860	−0.037	0.871	0.107	0.648	−0.150	0.374	−0.250	0.196	−0.346	0.089
Waist (cm)	−0.150	0.403	0.048	0.807	−0.186	0.362	−0.366	0.018	−0.237	0.157	−0.131	0.457
SBP (mmHg)	−0.094	0.271	−0.064	0.643	−0.220	0.069	−0.241	0.001	−0.378	0.002	−0.203	0.053
Cre (mg/dL)	−0.046	0.644	0.054	0.732	−0.031	0.824	−0.076	0.375	0.010	0.941	−0.073	0.548
HbA1c (%)	−0.186	0.034	−0.155	0.314	−0.138	0.207	−0.009	0.907	0.011	0.931	−0.006	0.953
Log [TG (mg/dL)]	0.000	0.999	−0.035	0.836	0.110	0.355	−0.098	0.231	−0.057	0.691	−0.096	0.350
HDL-C (md/dL)	0.097	0.325	0.079	0.625	0.046	0.703	−0.125	0.134	−0.078	0.564	−0.233	0.027
LDL-C (mg/dL)	−0.051	0.554	−0.107	0.432	0.014	0.912	−0.050	0.494	0.045	0.694	−0.189	0.087
Smoking (yes = 1)	−0.080	0.378	−0.053	0.702	−0.049	0.712	0.026	0.732	0.064	0.580	−0.039	0.730
Insulin (yes = 1)	−0.050	0.572	−0.175	0.236	0.056	0.646	−0.073	0.338	−0.155	0.210	−0.066	0.530
Statins (yes = 1)	0.008	0.915	0.037	0.768	−0.035	0.747	−0.030	0.652	0.008	0.942	−0.032	0.727
ARB/ACEI (yes = 1)	−0.104	0.209	−0.069	0.576	−0.171	0.151	−0.040	0.572	−0.020	0.846	−0.019	0.851
Log [Leptin (ng/mL)]	0.158	0.246	0.038	0.859	0.427	0.013	0.341	0.004	0.462	0.011	0.318	0.031
R²	0.132	0.094	0.111	0.885	0.310	0.025	0.372	<0.001	0.376	0.002	0.485	<0.001

β, standard correlation coefficient by multiple regression analysis; R², multiple coefficients of determination. Abbreviations are the same as Table 1.

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