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Table 1 Comparison of four- and five-period crossover designs for TQT studies leading to the same statistical power

From: The sodium glucose cotransporter 2 inhibitor empagliflozin does not prolong QT interval in a thorough QT (TQT) study

  Typical four-period
TQT design
New five-period
TQT design
Placebo periods 1 2
Placebo sessions 40 60
Supratherapeutic dose sessions 40 30
Therapeutic dose sessions 40 30
Active control sessions 40 30
Total number of sessions 160 150
  1. TQT, thorough QT.