Figure 1

Activation of TRPV1 up-regulates UCP2 through PKA phosphorylation. A, B and C: Representative western blot images showing protein expressions of TRPV1 (A), p-PKA/PKA (B) and UCP2 (C) in endothelial cells cultured with normal-glucose (NG, glucose 5.5 mmol/L), high-glucose (HG, glucose 30 mmol/L), HG+capsaicin (HG+Cap, Cap 1 μmol/L), HG+Cap+5’-iodo-resiniferatoxin (HG+Cap+iRTX, iRTX 1 μmol/L), HG+Cap+KT5720 (2 μmol/L) or HG+Cap+Genipin (10 μmol/L); #P<0.05, ##P<0.01 versus NG group; *P<0.05, **P<0.01 versus HG group; ΔP<0.05, ΔΔP<0.01 versus HG+Cap group. Data are mean ± SEM. Each n = 3.