Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1β/ErbB in response to myocardial infarction resulting in worsening heart failure

Table 1 Animal characteristics at 4 weeks post-MI

Parameter	CV	DM	Sham MI	MI	DM + MI
Body Weight, g	365 ± 10.6	225 ± 11.6^*	356 ± 7.0	376 ± 9.4^#	227 ± 7.7*^†‡
Blood Glucose, mg/dl	152 ± 6.1	547 ± 20.2^*	142 ± 7.3	163 ± 5.2^#	549 ± 13.9^*†‡
Total Heart Weight, g	1.2 ± 0.03	0.9 ± 0.08^*	1.3 ± 0.03	1.5 ±0.05^†#	1.3 ± 0.06^#‡
Scar Weight, g	ND	ND	ND	0.20 ±0.03	0.19 ± 0.02
Lung Wet/Dry	4.8 ± 0.03	4.8 ± 0.08	5.1 ± 0.11	5.0 ± 0.09	5.3 ± 0.08^*#‡
Liver Wet/Dry	3.3 ± 0.12	3.0 ± 0.11	3.2 ± 0.05	3.1 ± 0.12	3.3 ± 0.04

Values are mean ± standard error of the mean of four to six animals. ND: not detectable. CV, control vehicle; DM, diabetes mellitus; Sham MI, sham myocardial infarction, MI, myocardial infarction; DM + MI, diabetes mellitus + myocardial infarction. ^*P < 0.05 vs. CV; ^†P < 0.05 vs. Sham MI; ^#P < 0.05 vs. DM; ^‡P < 0.05 vs. MI.

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