Figure 6
From: Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta
Proposed mechanism accounting for signal transduction pathways towards the role of RhoA/Rho-kinase signaling in endothelium-dependent both contractile and relaxation activities in thoracic aorta from diabetic rats. See discussion for details. NO, nitric oxide; eNOS, endothelial nitric oxide synthase; ROCK, RhoA/Rho-kinase, pMLC, phospho-myosin light chain; pMLCP, phospho-MLC phosphatase.