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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Antidiabetic treatment restores adiponectin serum levels and APPL1 expression, but does not improve adiponectin-induced vasodilation and endothelial dysfunction in Zucker diabetic fatty rats

Figure 4

Dose-dependent relaxation of resistance arteries to cumulative doses of acetylcholine (ACh) after precontraction with norepinephrine. Acetylcholine-induced vasodilation is diminished in ZDF animals indicating endothelial dysfunction, which can´ t be improved by insulin or metformin. Two-way ANOVA for repeated measurements: * p < 0.001 vs. ZDF, ZDF+I and ZDF+M; # p = 0.004 vs. ZDF.

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Cardiovascular Diabetology

ISSN: 1475-2840