Wild type | Ob/ob | DKO | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Condition | Sham | NP | P | Sham | NP | P | Sham | NP | P | |
PRSW (mmHg) | Untreated | 87.9±5.0 | 60.2±11.8c | 76.3±5.4 cd | 64.5±2.5 a | 48.1±3.6 ac | 57.1±5.2 acd | 58.0±4.1 af | 48.6±6.5 ac | 49.2±3.0 acf |
Diet | 65.8±1.7 | 50.4±1.0 c | 64.4±3.1 bd | 58.2±3.0 f | 49.5±3.2 c | 55.9±3.5 bdf | ||||
ACE-I | 88.0±4.6 | 59.3±6.8 c | 81.2±3.1 bcd | 72.4±3.1 abe | 52.3±3.6 ac | 69.8±2.9 abde | 65.9±5.3 abef | 51.1±3.6 ac | 63.9±3.3 abdef | |
Ees (mmHg/μl) | Untreated | 8.3±2.5 | 6.4±1.5 | 8.5±1.7 d | 5.0±0.4 a | 4.8±1.7 | 5.6±1.2 a | 6.0±2.2 | 4.5±0.8 a | 4.8±2.3 a |
Diet | 6.3±2.2 | 4.4±1.2 | 7.3±2.2d | 5.1±1.3 | 5.4±1.2 | 5.6±1.1 | ||||
ACE-I | 6.0±1.1 | 6.2±1.6 | 8.7±1.7 cd | 5.3±1.7 | 4.2±1.3 | 6.4±1.6 ad | 5.6±1.4 | 4.3±1.4 | 5.2±3.0 a | |
EDPVR (mmHg/μl) | Untreated | 0.2±0.2 | 0.4±0.2 | 0.3±0.2 | 0.4±0.3 | 0.4±0.3 | 0.5±0.3 a | 0.5±0.4 | 0.3±0.1 | 0.3±0.2 |
Diet | 0.3±0.2 | 0.2±0.1 | 0.2±0.1 b | 0.3±0.1 | 0.2±0.1 b | 0.3±0.2 | ||||
ACE-I | 0.2±0.2 | 0.4±0.4 | 0.2±0.1 | 0.4±0.1 | 0.3±0.1 | 0.3±0.1 bc | 0.3±0.1 f | 0.3±0.1 | 0.2±0.1 |