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Table 1 Load-independent hemodynamic parameters

From: Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice

  

Wild type

Ob/ob

DKO

 

Condition

Sham

NP

P

Sham

NP

P

Sham

NP

P

PRSW (mmHg)

Untreated

87.9±5.0

60.2±11.8c

76.3±5.4 cd

64.5±2.5 a

48.1±3.6 ac

57.1±5.2 acd

58.0±4.1 af

48.6±6.5 ac

49.2±3.0 acf

Diet

   

65.8±1.7

50.4±1.0 c

64.4±3.1 bd

58.2±3.0 f

49.5±3.2 c

55.9±3.5 bdf

ACE-I

88.0±4.6

59.3±6.8 c

81.2±3.1 bcd

72.4±3.1 abe

52.3±3.6 ac

69.8±2.9 abde

65.9±5.3 abef

51.1±3.6 ac

63.9±3.3 abdef

Ees (mmHg/μl)

Untreated

8.3±2.5

6.4±1.5

8.5±1.7 d

5.0±0.4 a

4.8±1.7

5.6±1.2 a

6.0±2.2

4.5±0.8 a

4.8±2.3 a

Diet

   

6.3±2.2

4.4±1.2

7.3±2.2d

5.1±1.3

5.4±1.2

5.6±1.1

ACE-I

6.0±1.1

6.2±1.6

8.7±1.7 cd

5.3±1.7

4.2±1.3

6.4±1.6 ad

5.6±1.4

4.3±1.4

5.2±3.0 a

EDPVR (mmHg/μl)

Untreated

0.2±0.2

0.4±0.2

0.3±0.2

0.4±0.3

0.4±0.3

0.5±0.3 a

0.5±0.4

0.3±0.1

0.3±0.2

Diet

   

0.3±0.2

0.2±0.1

0.2±0.1 b

0.3±0.1

0.2±0.1 b

0.3±0.2

ACE-I

0.2±0.2

0.4±0.4

0.2±0.1

0.4±0.1

0.3±0.1

0.3±0.1 bc

0.3±0.1 f

0.3±0.1

0.2±0.1

  1. ACE-I: angiotensin-converting enzyme inhibition; DKO: double knock-out (ob/ob; LDLR-/-); EDPVR: end-diastolic pressure-volume relationship; Ees: end-systolic elastance; IR: ischemia/reperfusion; NP: Non-Preconditioned and ischemia/reperfusion; P: Preconditioned and ischemia/reperfusion; PRSW: preload recruitable stroke work; sham: group without ischemia/reperfusion. “a” p<0.05 versus WT same treatment, same condition (sham; non-preconditioned; preconditioned); “b” p<0.05 versus same untreated genotype, same condition; “c” p<0.05 versus sham, same genotype, same treatment; “d” p<0.05 versus non-preconditioned, same genotype, same treatment; “e” p<0.05 versus diet, same genotype, same condition; “f” p<0.05 versus ob/ob same treatment, same condition.