VPC 23109 attenuates HDL-induced HUVEC COX-2 expression and PGI-2 release. VPC 23019 attenuated HDL-induced COX-2 expression (A, B) and PGI-2 release (C) by HUVECs. In these experiments, cells were pre-treated VPC 23019 (2 nmol/ml) for 20 minutes and then incubated with 30 μg/ml of N-HDL or D-HDL for further 6 hours. The measurements of COX-2 expression (A, B) and PGI-2 release (C) were same as above. In all experiments above, PBS was used as vehicle control. Data are expressed as the means ± SEM of three independent experiments. Student’s t test. * p < 0.05. ** p < 0.01, *** p < 0.001.