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Figure 4 | Cardiovascular Diabetology

Figure 4

From: High-density lipoprotein of patients with Type 2 Diabetes Mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate

Figure 4

VPC 23109 attenuates HDL-induced HUVEC COX-2 expression and PGI-2 release. VPC 23019 attenuated HDL-induced COX-2 expression (A, B) and PGI-2 release (C) by HUVECs. In these experiments, cells were pre-treated VPC 23019 (2 nmol/ml) for 20 minutes and then incubated with 30 μg/ml of N-HDL or D-HDL for further 6 hours. The measurements of COX-2 expression (A, B) and PGI-2 release (C) were same as above. In all experiments above, PBS was used as vehicle control. Data are expressed as the means ± SEM of three independent experiments. Student’s t test. * p < 0.05. ** p < 0.01, *** p < 0.001.

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Cardiovascular Diabetology

ISSN: 1475-2840