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Table 1 Echocardiography measurements in control, diabetic (10 wks), and treatment groups

From: Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors

 

Control

STZ + Veh

STZ + Alsk

STZ + Benz

STZ + Vals

STZ + PD + Vals

HR

477 ± 20

473 ± 12

456 ± 21

452 ± 21

438 ± 13

447 ± 26

CO

24 ± 1.90

15.8 ± 0.62*

22.5 ± 1.66†

21.82 ± 1.98†

21.48 ± 1.87†

17.96 ± 0.84*

SV

52.8 ± 1.60

35.9 ± 1.60*

45.3 ± 2.40*†

47.51 ± 3.10†

47.82 ± 3.20†

39.76 ± 1.70*

IVCT

15.5 ± 0.60

17.9 ± 0.60*

15.2 ± 0.50†

15.2 ± 0.20†

15.5 ± 0.70†

16.8 ± 1.40

LVPWd

0.93 ± 0.03

0.90 ± 0.02

0.89 ± 0.03

0.94 ± 0.02

0.96 ± 0.04

1.15 ± 0.08†

LVPWs

1.29 ± 0.07

1.15 ± 0.09

1.37 ± 0.02

1.34 ± 0.06

1.28 ± 0.03

1.27 ± 0.06

IVSd

0.93 ± 0.03

0.87 ± 0.03

0.89 ± 0.03

0.98 ± 0.02†

0.93 ± 0.03

0.81 ± 0.04

IVSs

1.36 ± 0.05

0.96 ± 0.05*

1.38 ± 0.05†

1.40 ± 0.03†

1.30 ± 0.05†

1.21 ± 0.06†

LVIDd

3.91 ± 0.09

3.79 ± 0.10

3.42 ± 0.09*

3.47 ± 0.14*

3.68 ± 0.12

3.72 ± 0.12

LVIDs

2.83 ± 0.15

2.57 ± 0.13

2.34 ± 0.10*

2.42 ± 0.18

2.61 ± 0.10

2.67 ± 0.13

E'/A'

0.90 ± 0.04

0.67 ± 0.06*

0.84 ± 0.04

0.80 ± 0.05

0.81 ± 0.02

0.76 ± 0.11

  1. For control group, n = 8; STZ + Veh, n = 9; STZ + Alsk, n = 8; STZ + Benz, n = 9; STZ + Vals, n = 7; STZ + Vals + PD, n = 7. CO = cardiac output (mls/min), SV = stroke volume (μl), IVCT = isovolumic contraction time (ms), LVPWd = left ventricular posterior wall thickness in diastole (mm), LVPWs = left ventricular posterior wall thickness in systole, IVSd = interventricular septum thickness in diastole (mm), IVSs = interventricular septum thickness in systole, LVIDd = left ventricular internal dimension in diastole, LVIDs = left ventricular internal dimension in systole (mm), E’A’ = mitral annulus tissue Doppler velocities. * = p < 0.05 vs. Control; † = p < 0.05 vs. STZ + Veh.