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Table 1 Echocardiography measurements in control, diabetic (10 wks), and treatment groups

From: Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors

  Control STZ + Veh STZ + Alsk STZ + Benz STZ + Vals STZ + PD + Vals
HR 477 ± 20 473 ± 12 456 ± 21 452 ± 21 438 ± 13 447 ± 26
CO 24 ± 1.90 15.8 ± 0.62* 22.5 ± 1.66 21.82 ± 1.98 21.48 ± 1.87 17.96 ± 0.84*
SV 52.8 ± 1.60 35.9 ± 1.60* 45.3 ± 2.40* 47.51 ± 3.10 47.82 ± 3.20 39.76 ± 1.70*
IVCT 15.5 ± 0.60 17.9 ± 0.60* 15.2 ± 0.50 15.2 ± 0.20 15.5 ± 0.70 16.8 ± 1.40
LVPWd 0.93 ± 0.03 0.90 ± 0.02 0.89 ± 0.03 0.94 ± 0.02 0.96 ± 0.04 1.15 ± 0.08
LVPWs 1.29 ± 0.07 1.15 ± 0.09 1.37 ± 0.02 1.34 ± 0.06 1.28 ± 0.03 1.27 ± 0.06
IVSd 0.93 ± 0.03 0.87 ± 0.03 0.89 ± 0.03 0.98 ± 0.02 0.93 ± 0.03 0.81 ± 0.04
IVSs 1.36 ± 0.05 0.96 ± 0.05* 1.38 ± 0.05 1.40 ± 0.03 1.30 ± 0.05 1.21 ± 0.06
LVIDd 3.91 ± 0.09 3.79 ± 0.10 3.42 ± 0.09* 3.47 ± 0.14* 3.68 ± 0.12 3.72 ± 0.12
LVIDs 2.83 ± 0.15 2.57 ± 0.13 2.34 ± 0.10* 2.42 ± 0.18 2.61 ± 0.10 2.67 ± 0.13
E'/A' 0.90 ± 0.04 0.67 ± 0.06* 0.84 ± 0.04 0.80 ± 0.05 0.81 ± 0.02 0.76 ± 0.11
  1. For control group, n = 8; STZ + Veh, n = 9; STZ + Alsk, n = 8; STZ + Benz, n = 9; STZ + Vals, n = 7; STZ + Vals + PD, n = 7. CO = cardiac output (mls/min), SV = stroke volume (μl), IVCT = isovolumic contraction time (ms), LVPWd = left ventricular posterior wall thickness in diastole (mm), LVPWs = left ventricular posterior wall thickness in systole, IVSd = interventricular septum thickness in diastole (mm), IVSs = interventricular septum thickness in systole, LVIDd = left ventricular internal dimension in diastole, LVIDs = left ventricular internal dimension in systole (mm), E’A’ = mitral annulus tissue Doppler velocities. * = p < 0.05 vs. Control;  = p < 0.05 vs. STZ + Veh.