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Table 4 Association of copeptin levels and IMT according to categories of glucose homeostasis

From: Plasma copeptin levels are inversely associated with intima-media-thickness in men: the population-based KORA F4 study

  Copeptin Copeptin Copeptin β per 1 SD increase in copeptin
Q3-4 vs Q1-2 Q4 vs Q1-Q3 Q4 vs Q1
Total study cohort  
No adjustment  
NGT (n = 911) 0.007 0.019 0.024 0.001
(-0.010; 0.025) (-0.002; 0.040) (-0.001; 0.049) (-0.008; 0.010)
Prediabetes (n = 224) -0.010 -0.009 -0.024 -0.011
(-0.046; 0.027) (-0.049; 0.031) (-0.075; 0.027) (-0.055; 0.032)
T2D (n = 140) -0.018 -0.003 0.001 0.009
(-0.068; 0.032) (-0.051; 0.046) (-0.076; 0.077) (-0.006; 0.024)
Adjustment for age and sex  
NGT -0.015 -0.004 -0.007 -0.004
(-0.029; -0.002) (-0.020; 0.012) (-0.026; 0.012) (-0.011; 0.002)
Prediabetes -0.028 -0.040 -0.058 -0.044
(-0.060; 0.004) (-0.075; -0.005) (-0.103; -0.014) (-0.082; -0.006)
T2D -0.025 -0.009 -0.008 0.010
(-0.071; 0.020) (-0.054; 0.035) (-0.078; 0.062) (-0.003; 0.024)
Adjusted for age, sex and BMI  
NGT -0.016 -0.006 -0.008 -0.005
(-0.029; -0.003) (-0.022; 0.010) (-0.027; 0.011) (-0.012; 0.002)
Prediabetes -0.027 -0.038 -0.057 -0.042
(-0.058; 0.005) (-0.073; -0.004) (-0.101; -0.013) (-0.079; -0.004)
T2D -0.025 -0.008 -0.007 0.010
(-0.070; 0.021) (-0.053; 0.037) (-0.078; 0.063) (-0.003; 0.024)
Multivariable adjustment a  
NGT -0.018 -0.007 -0.009 -0.006
(-0.031; -0.005) (-0.023; 0.008) (-0.028; 0.010) (-0.013; 0.0002)
Prediabetes -0.031 -0.041 -0.066 -0.050
(-0.064; 0.002) (-0.078; -0.005) (-0.112; -0.019) (-0.091; -0.009)
T2D -0.030 -0.009 -0.018 0.012
(-0.081; 0.020) (-0.059; 0.040) (-0.096; 0.060) (-0.002; 0.026)
  1. Gender-specific adjusted β’s (95% CI) according to categories of glucose tolerance for IMT as dependent variable and categories of copeptin as independent variable (highest quartile Q4 or Q3-4 versus lower quartiles (reference)): Results of linear regression models.
  2. aAdjusted for: age, sex, BMI, waist (continuous), hypertension (systolic blood pressure ≥ 140/90 mm Hg or antihypertensive medication), HDL cholesterol (continuous), LDL cholesterol (continuous), triglycerides (continuous), former myocardial infarction or stroke, smoking (active/former/never), alcohol consumption (abstinent/moderate/high), physical activity (high/low), hsCRP, eGFR.
  3. bold: p < 0.05.