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Table 4 Association of copeptin levels and IMT according to categories of glucose homeostasis

From: Plasma copeptin levels are inversely associated with intima-media-thickness in men: the population-based KORA F4 study

 

Copeptin

Copeptin

Copeptin

β per 1 SD increase in copeptin

Q3-4 vs Q1-2

Q4 vs Q1-Q3

Q4 vs Q1

Total study cohort

 

No adjustment

 

NGT (n = 911)

0.007

0.019

0.024

0.001

(-0.010; 0.025)

(-0.002; 0.040)

(-0.001; 0.049)

(-0.008; 0.010)

Prediabetes (n = 224)

-0.010

-0.009

-0.024

-0.011

(-0.046; 0.027)

(-0.049; 0.031)

(-0.075; 0.027)

(-0.055; 0.032)

T2D (n = 140)

-0.018

-0.003

0.001

0.009

(-0.068; 0.032)

(-0.051; 0.046)

(-0.076; 0.077)

(-0.006; 0.024)

Adjustment for age and sex

 

NGT

-0.015

-0.004

-0.007

-0.004

(-0.029; -0.002)

(-0.020; 0.012)

(-0.026; 0.012)

(-0.011; 0.002)

Prediabetes

-0.028

-0.040

-0.058

-0.044

(-0.060; 0.004)

(-0.075; -0.005)

(-0.103; -0.014)

(-0.082; -0.006)

T2D

-0.025

-0.009

-0.008

0.010

(-0.071; 0.020)

(-0.054; 0.035)

(-0.078; 0.062)

(-0.003; 0.024)

Adjusted for age, sex and BMI

 

NGT

-0.016

-0.006

-0.008

-0.005

(-0.029; -0.003)

(-0.022; 0.010)

(-0.027; 0.011)

(-0.012; 0.002)

Prediabetes

-0.027

-0.038

-0.057

-0.042

(-0.058; 0.005)

(-0.073; -0.004)

(-0.101; -0.013)

(-0.079; -0.004)

T2D

-0.025

-0.008

-0.007

0.010

(-0.070; 0.021)

(-0.053; 0.037)

(-0.078; 0.063)

(-0.003; 0.024)

Multivariable adjustment a

 

NGT

-0.018

-0.007

-0.009

-0.006

(-0.031; -0.005)

(-0.023; 0.008)

(-0.028; 0.010)

(-0.013; 0.0002)

Prediabetes

-0.031

-0.041

-0.066

-0.050

(-0.064; 0.002)

(-0.078; -0.005)

(-0.112; -0.019)

(-0.091; -0.009)

T2D

-0.030

-0.009

-0.018

0.012

(-0.081; 0.020)

(-0.059; 0.040)

(-0.096; 0.060)

(-0.002; 0.026)

  1. Gender-specific adjusted β’s (95% CI) according to categories of glucose tolerance for IMT as dependent variable and categories of copeptin as independent variable (highest quartile Q4 or Q3-4 versus lower quartiles (reference)): Results of linear regression models.
  2. aAdjusted for: age, sex, BMI, waist (continuous), hypertension (systolic blood pressure ≥ 140/90 mm Hg or antihypertensive medication), HDL cholesterol (continuous), LDL cholesterol (continuous), triglycerides (continuous), former myocardial infarction or stroke, smoking (active/former/never), alcohol consumption (abstinent/moderate/high), physical activity (high/low), hsCRP, eGFR.
  3. bold: p < 0.05.