High sensitive C-reactive protein and serum amyloid A are inversely related to serum bilirubin: effect-modification by metabolic syndrome

Table 3 Multivariable linear regression analyses on the interaction of MetS or T2DM with bilirubin on SAA

	Model A (n = 167)		Model B (n = 167)		Model C (n = 167)		Model D (n = 167)
	β	P-value	β	P-value	β	P-value	β	P-value
Age	−0.033	0.67	−0.025	0.75	−0.045	0.57	−0.033	0.67
Sex (men/women)	−0.087	0.26	−0.101	0.21	−0.101	0.20	−0.108	0.19
MetS (yes/no)	0.133	0.02	0.118	0.16
T2DM (yes/no)					0.142	0.075	0.085	0.32
Total bilirubin	−0.317	0.011	−0.311	0.013	−0.266	0.043	−0.246	0.061
*Interaction MetS total bilirubin**	0.336	0.006	0.321	0.009
*Interaction T2DM total bilirubin**					0.245	0.056	0.218	0.089
Alcohol intake			−0.098	0.21			−0.115	0.14
ALT			0.098	0.28			0.093	0.32
AST			0.059	0.48			0.072	0.40

ALT: aminotransferase; AST: aspartate aminotransferase; MetS: metabolic syndrome; SAA: serum amyloid A; T2DM: type 2 diabetes mellitus; β: standardized regression coefficient.
Model A: includes age, sex, bilirubin, MetS, T2DM and interaction of MetS with bilirubin.
Model B: additionally includes alcohol intake and transaminases.
Model C: model including age, sex, bilirubin, MetS, T2DM and interaction of T2DM with bilirubin.
Model D: additionally includes alcohol intake and transaminases.

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