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Table 5 Gene ontology analysis

From: Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats

Category

GO ID

Level

Term

Count

%

p value

Genes (gene symbols)

GOTERM_BP_ALL

GO:0009987

02

cellular process

47

55,3

0,035

ACAN, ACOT1, ACOT7, ANGPTL4, APBA1, ARID2, ARNTL, ASS1, ATF3, ATP1B4, ATP12A,BCL2A1D, BEX1, CAMK2G, CBR1, CHRNG, COL24A1, CSGALNACT1, CTGF, DCXR, DLG4, DUSP3, EXO1, GSTA5, HAP1, HDAC5, HEY2, HIPK2, HMGCS2, HSPA1A, HSPA1B, HNRPLL, IRX3, LOC360228, LOC501189, NGFR, NNAT, NTSR2, PCK2, SNED1, SPTBN2, ST8SIA4, STRBP, TAF13, TGM1, TYMS, UCHL1

GOTERM_BP_ALL

GO:0009266

04

response to temperature stimulus

5

5,9

0,013

CIRBP, HSPA1A, HSPA1B, IL18, NGFR

GOTERM_BP_ALL

GO:0042180

04

cellular ketone metabolic process

9

10,6

0,004

ACOT1, ACOT7, ARID2, ASS1, ATF3, CBR1, CSGALNACT1, HNRPLL, PCK2

GOTERM_BP_ALL

GO:0006082

04

organic acid metabolic process

8

9,4

0,014

ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2

GOTERM_BP_ALL

GO:0019752

05

carboxylic acid metabolic process

8

9,4

0,014

ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2

GOTERM_BP_ALL

GO:0043436

05

oxoacid metabolic process

8

9,4

0,014

ACOT1, ACOT7, ARID2, ASS1, ATF3, CSGALNACT1, HNRPLL, PCK2

GOTERM_BP_ALL

GO:0034637

05

cellular carbohydrate biosynthetic process

3

3,5

0,039

ATF3, CSGALNACT1, PCK2

GOTERM_BP_ALL

GO:0051346

06

negative regulation of hydrolase activity

4

4,7

0,023

ANGPTL4, BCL2A1D, HSPA1A, HSPA1B,

GOTERM_BP_ALL

GO:0008284

06

positive regulation of cell proliferation

6

7,1

0,039

ATF3, BEX1, HEY2, HIPK2, IL18, NGFR

GOTERM_BP_ALL

GO:0048489

07

synaptic vesicle transport

3

3,5

0,017

APBA1, DLG4, SPTBN2

GOTERM_BP_ALL

GO:0032502

02

developmental process

25

29,4

0,001

ACAN, ANGPTL4, APBA1, ASS1, ATF3, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, HIPK2, IL18, IRX3, KLK14, LOC360228, NGFR, NNAT, NRG2, ODZ4, STRBP, TGM1, UCHL1

GOTERM_BP_ALL

GO:0048869

03

cellular developmental process

15

17,6

0,012

ACAN, ANGPTL4, ATF3, BCL2A1D, BEX1, CTGF, DLG4, HEY2, IRX3, LOC360228, NGFR, NNAT, STRBP, TGM1, UCHL1

GOTERM_BP_ALL

GO:0007275

03

multicellular organismal development

23

27,1

0,001

ACAN, ANGPTL4, APBA1, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1,HEY2, HAP1, HIPK2, IL18, IRX3, KLK14, NGFR, NNAT, NRG2, ODZ4, STRBP, TGM1, UCHL1

GOTERM_BP_ALL

GO:0048856

03

anatomical structure development

19

22,3

0,013

ACAN, ANGPTL4, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, IL18, IRX3, KLK14, NGFR, NNAT, ODZ4, TGM1, UCHL1

GOTERM_BP_ALL

GO:0048731

04

system development

18

21,1

0,016

ACAN, ANGPTL4, ASS1, BCL2A1D, BEX1, CBR1, CTGF, DLG4, EXO1, HAP1, HEY2, IL18, IRX3, KLK14, NGFR, NNAT, TGM1, UCHL1

GOTERM_BP_ALL

GO:0030154

04

cell differentiation

15

17,6

0,009

ACAN, ANGPTL4 ATF3, BCL2A1D, BEX1, CTGF, DLG4, HEY2, IRX3, LOC360228, NGFR, NNAT, STRBP, TGM1, UCHL1

GOTERM_MF_ALL

GO:0003824

02

catalytic activity

30

35,3

0,037

ACOT1, ACOT7, ARID2, ASS1, ATP1B4, ATP12A ,BDH1, CAMK2G, CBR1, CSGALNACT1, DCXR, DUSP3, EXO1,GCAT, GSTA5, HDAC5, HIPK2, HMGCS2, KLK14, LOC286911, LOC501189, MYO9A, PCK2, PLA2G7, RAB7A, RNASE1, ST8SIA4, TYMS, TGM1, UCHL1

GOTERM_MF_ALL

GO:0016788

04

hydrolase activity, acting on ester bonds

7

8,2

0,041

ACOT1, ACOT7, DUSP3, EXO1, PLA2G7, RNASE1, UCHL1

GOTERM_MF_ALL

GO:0016790

05

thiolester hydrolase activity

3

3,5

0,047

ACOT1, ACOT7, UCHL1

GOTERM_CC_ALL

GO:0031974

02

membrane-enclosed lumen

13

14,5

0,032

ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13

GOTERM_CC_ALL

GO:0044421

03

extracellular region part

8

9,6

0,044

ACAN, ANGPTL4, COL24A1, CTGF, LOC286911, LOC360228, IL18, KLK14

GOTERM_CC_ALL

GO:0031090

04

organelle membrane

11

12,0

0,032

ASS1, CAMK2G, CSGALNACT1, BDH1, DLG4, GCAT, GSTA5, HIPK2, HMGCS2, LOC501189, ST8SIA4

GOTERM_CC_ALL

GO:0043233

04

organelle lumen

13

15,3

0,027

ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13

GOTERM_CC_ALL

GO:0070013

06

intracellular organelle lumen

13

15,3

0,021

ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, BDH1, CIRBP, DUSP3, HIPK2, HMGCS2, NGFR, SPTBN2, SUPT16H, TAF13

GOTERM_CC_ALL

GO:0005654

06

nucleoplasm

9

10,6

0,045

ARNTL, ASCL3, ASCL3_PREDICTED, CIRBP, DUSP3, HIPK2, NGFR, SUPT16H, TAF13

GOTERM_CC_ALL

GO:0031981

07

nuclear lumen

12

14,1

0,029

ARNTL, ASCL3, ASCL3_PREDICTED, ATF3, CIRBP, DUSP3, HIPK2, NGFR, SPTBN2, SUPT16H, TAF13

GOTERM_CC_ALL

GO:0030139

08

endocytic vesicle

3

3,5

0,034

CAMK2G, DLG4, RAB7A

  1. Significantly enriched gene ontology (GO) terms in the population of genes with altered expression due to metabolic syndrome. GO analysis determines the biological significance of differentially expressed genes that can be used to determine the functional classification of the genes, the expression of which have been significantly up- or down-regulated. Major functional categories of GO terms were separated by horizontal lines, subcategories are represented by level on gene tree.
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Cardiovascular Diabetology

ISSN: 1475-2840