Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence

Table 3 Serum angiotensin-converting enzyme 2 (ace2) levels and myocardial infarction (mi) scores in control and acute mi subjects

Subjects		Genotype	N	Serum ACE2 level (ng/mL)	MI severity score
Total	Control	GG	269	6.8±4.5	N/A
		GA+AA	91	5.5±3.3
		Total	360	6.3±3.9
	Acute MI	GG	257	15.9±7.8^a	11.6±6.5
		GA+AA	94	8.1±5.4^b,c	18.8±4.4^c
		Total	351	13.7±7.2	13.5±4.9
Male	Control	GG	144	6.6±4.7	N/A
		GA+AA	63	5.2±3.5
		Total	207	6.2±4.2
	Acute MI	GG	156	15.7±8.0^a	11.7±6.7
		GA+AA	69	7.8±5.5^b,c	19.0±4.6^c
		Total	225	13.3±7.5	13.8±5.2
Female	Control	GG	125	7.0±4.4	N/A
		GA+AA	28	6.2±3.1
		Total	153	6.9±3.5
	Acute MI	GG	101	16.2±7.5^a	11.4±6.2
	Acute MI	GA+AA	25	8.9±5.2^b,c	18.2±4.0^c
		Total	126	14.8±8.0	12.8±4.4

Note: Comparisons of means among genotype groups were performed with one-way ANOVA followed by post hoc pairwise comparisons using Tukey's tests in total subjects and by gender. ^ap<0.05 compared with GG in Control subjects; ^bp<0.05 compared with GA+AA in Control subjects; ^cp<0.05 compared with GG in Acute MI subjects.

ISSN: 1475-2840