Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

Table 2 Plasma metabolites from control and diabetic rats in the fed state, induced using high-fat feeding in combination with low dose STZ

		Diabetes model
		(High-fat feeding with low dose STZ)
	Control	0 mg/kg	15 mg/kg	20 mg/kg	25 mg/kg	30 mg/kg
Glucose (mmol/l)	12.7 ± 0.3	14.6 ± 1.8	14.7 ± 0.6	17.2 ± 1.2 *	16.9 ± 1.5 *	25.1 ± 1.1 *†
Insulin (ug/l)	3.03 ± 0.51	2.68 ± 0.57	2.00 ± 0.31	1.59 ± 0.36	1.93 ± 0.26	1.04 ± 0.22 *
NEFA (mmol/l)	0.28 ± 0.06	0.29 ± 0.05	0.29 ± 0.02	0.29 ± 0.01	0.14 ± 0.04	0.59 ± 0.07 *#
Triglycerides (mmol/l)	1.79 ± 0.20	1.13 ± 0.22	0.87 ± 0.06	1.41 ± 0.15	1.79 ± 0.35	7.25 ± 1.33 *†
β-OHB (mmol/l)	0.26 ± 0.04	0.33 ± 0.04	0.45 ± 0.07	0.77 ± 0.06	0.98 ± 0.21	5.39 ± 0.59 *†
Cholesterol (mmol/l)	2.46 ± 0.13	2.07 ± 0.21	1.68 ± 0.15	2.11 ± 0.27	3.87 ± 0.58 *$	3.02 ± 0.44 €

* p < 0.05 vs. control, † p < 0.05 vs. all other doses of STZ, # p < 0.05 vs. 15 and 25 mg/kg, $ p < 0.05 vs. 0, 15 and 20 mg/kg, € p < 0.05 vs. 15 mg/kg. NEFA non-esterified fatty acids, β-OHB β-hydroxybutyrate, control n = 11, for diabetic groups n = 4.

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