| |
Diabetes model
|
|---|
|
(High-fat feeding with low dose STZ)
|
|---|
| |
Control
|
0 mg/kg
|
15 mg/kg
|
20 mg/kg
|
25 mg/kg
|
30 mg/kg
|
|---|
|
Glucose (mmol/l)
|
12.7 ± 0.3
|
14.6 ± 1.8
|
14.7 ± 0.6
|
17.2 ± 1.2 *
|
16.9 ± 1.5 *
|
25.1 ± 1.1 *†
|
|
Insulin (ug/l)
|
3.03 ± 0.51
|
2.68 ± 0.57
|
2.00 ± 0.31
|
1.59 ± 0.36
|
1.93 ± 0.26
|
1.04 ± 0.22 *
|
|
NEFA (mmol/l)
|
0.28 ± 0.06
|
0.29 ± 0.05
|
0.29 ± 0.02
|
0.29 ± 0.01
|
0.14 ± 0.04
|
0.59 ± 0.07 *#
|
|
Triglycerides (mmol/l)
|
1.79 ± 0.20
|
1.13 ± 0.22
|
0.87 ± 0.06
|
1.41 ± 0.15
|
1.79 ± 0.35
|
7.25 ± 1.33 *†
|
|
β-OHB (mmol/l)
|
0.26 ± 0.04
|
0.33 ± 0.04
|
0.45 ± 0.07
|
0.77 ± 0.06
|
0.98 ± 0.21
|
5.39 ± 0.59 *†
|
|
Cholesterol (mmol/l)
|
2.46 ± 0.13
|
2.07 ± 0.21
|
1.68 ± 0.15
|
2.11 ± 0.27
|
3.87 ± 0.58 *$
|
3.02 ± 0.44 €
|
- * p < 0.05 vs. control, † p < 0.05 vs. all other doses of STZ, # p < 0.05 vs. 15 and 25 mg/kg, $ p < 0.05 vs. 0, 15 and 20 mg/kg, € p < 0.05 vs. 15 mg/kg. NEFA non-esterified fatty acids, β-OHB β-hydroxybutyrate, control n = 11, for diabetic groups n = 4.
