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Table 2 Plasma metabolites from control and diabetic rats in the fed state, induced using high-fat feeding in combination with low dose STZ

From: Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

  Diabetes model
(High-fat feeding with low dose STZ)
  Control 0 mg/kg 15 mg/kg 20 mg/kg 25 mg/kg 30 mg/kg
Glucose (mmol/l) 12.7 ± 0.3 14.6 ± 1.8 14.7 ± 0.6 17.2 ± 1.2 * 16.9 ± 1.5 * 25.1 ± 1.1 *†
Insulin (ug/l) 3.03 ± 0.51 2.68 ± 0.57 2.00 ± 0.31 1.59 ± 0.36 1.93 ± 0.26 1.04 ± 0.22 *
NEFA (mmol/l) 0.28 ± 0.06 0.29 ± 0.05 0.29 ± 0.02 0.29 ± 0.01 0.14 ± 0.04 0.59 ± 0.07 *#
Triglycerides (mmol/l) 1.79 ± 0.20 1.13 ± 0.22 0.87 ± 0.06 1.41 ± 0.15 1.79 ± 0.35 7.25 ± 1.33 *†
β-OHB (mmol/l) 0.26 ± 0.04 0.33 ± 0.04 0.45 ± 0.07 0.77 ± 0.06 0.98 ± 0.21 5.39 ± 0.59 *†
Cholesterol (mmol/l) 2.46 ± 0.13 2.07 ± 0.21 1.68 ± 0.15 2.11 ± 0.27 3.87 ± 0.58 *$ 3.02 ± 0.44 €
  1. * p < 0.05 vs. control, † p < 0.05 vs. all other doses of STZ, # p < 0.05 vs. 15 and 25 mg/kg, $ p < 0.05 vs. 0, 15 and 20 mg/kg, € p < 0.05 vs. 15 mg/kg. NEFA non-esterified fatty acids, β-OHB β-hydroxybutyrate, control n = 11, for diabetic groups n = 4.