| |
Controls
|
Normoalbuminuria
|
Elevated albuminuria
|
Controls vs. short duration, normo-albuminuria
|
Long duration, normo-vs. micro- vs. macroalbuminuria
|
|---|
| | |
Short duration
|
Long duration
|
Micro
|
Macro
|
p
|
p
|
|---|
|
n = 86
|
n = 69
|
n = 211
|
n = 163
|
n = 186
|
|---|
|
24 h-CASP (mmHg)
|
117 (116–119)
|
118 (117–119)
|
119 (118–120)
|
121 (120–121)
|
122 (121–122)
|
0.39
|
<0.001
|
|
Daytime CASP (mmHg)
|
122 (120–123)
|
122 (121–123)
|
121 (121–122)
|
123 (123–124)
|
125 (124–126)
|
0.60
|
<0.001
|
|
Nighttime CASP (mmHg)
|
109 (107–111)
|
110 (109–112)
|
112 (111–114)
|
114 (113–115)
|
116 (115–117)
|
0.30
|
<0.001
|
|
Office CASP (mmHg)
|
110 (107–112)
|
111 (109–113)
|
119 (117–121)
|
120 (118–122)
|
118 (115–120)
|
0.44
|
0.41
|
|
24 h-CPP (mmHg)
|
38 (36–40)
|
39 (37–41)
|
43 (42–44)
|
46 (44–47)
|
47 (46–49)
|
0.59
|
<0.001
|
|
Daytime CPP (mmHg)
|
39 (37–41)
|
40 (38–41)
|
43 (42–45)
|
46 (45–48)
|
48 (46–49)
|
0.74
|
<0.001
|
|
Nighttime CPP (mmHg)
|
36 (34–38)
|
37 (35–39)
|
41 (40–43)
|
44 (43–45)
|
46 (44–47)
|
0.54
|
<0.001
|
|
24 h brachial SBP (mmHg)
|
126 (125–128)
|
126 (125–128)
|
128 (126–129)
|
130 (127–131)
|
131 (130–132)
|
0.98
|
<0.001
|
|
Daytime brachial SBP (mmHg)
|
132 (129–134)
|
132 (130–134)
|
132 (130–134)
|
134 (133–135)
|
135 (134–136)
|
0.90
|
0.001
|
|
Nighttime brachial SBP (mmHg)
|
116 (114–118)
|
117 (115–119)
|
119 (118–121)
|
122 (120–123)
|
123 (122–125)
|
0.56
|
0.001
|
|
24 h-MAP (mmHg)
|
92 (89–95)
|
92 (90–95)
|
95 (94–97)
|
92 (90–93)
|
92 (90–94)
|
0.80
|
0.004
|
|
24 h heart rate (beats per minute)
|
65 (63–67)
|
67 (66–69)
|
72 (70–73)
|
70 (68–71)
|
73 (71–74)
|
0.08
|
0.005
|
- Estimated marginal means with 95% confidence intervals. P-values are for adjusted comparisons (ANCOVA) of controls to patients with short duration of normoalbuminuria or for comparison between patients with longstanding normoalbuminuria, microalbuminuria and macroalbuminuria. Adjustments were made for gender, age, 24 h-MAP (except for 24 h-MAP), 24 h HR, eGFR and smoking. Adjustments also included HbA1c and antihypertensive treatment when comparing patients with normoalbuminuria and long diabetes duration, microalbuminuria and macroalbuminuria.
- CASP: central aortic systolic pressure, CPP: central pulse pressure, SBP: systolic blood pressure, MAP: mean arterial pressure, microalbuminuria: 30-299 mg/24 h, macroalbuminuria > 300 mg/24 h.
