Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects

Table 3 Genotype and allele frequencies of rs9770242 by CAD status

	N	rs9770242				OR (95% CI)	P
		MAF	TT	TG	GG
Brazilian cohort
Without CAD	188	0.245	0.582 (n = 109)	0.351 (n = 66)	0.067 (n = 13)	1
With CAD	406	0.201	0.639 (n = 259)	0.323 (n = 131)	0.038 (n = 16)	1.36 (1.01 – 1.86)^a	0.05
With CAD	406	0.201	0.639 (n = 259)	0.323 (n = 131)	0.038 (n = 16)	1.46 (1.06 – 2.01)^b	0.02
North-American cohort
Without CAD	434	0.247	0.562 (n = 244)	0.383 (n = 166)	0.055 (n = 24)	1
With CAD	424	0.245	0.543 (n = 230)	0.424 (n = 180)	0.033 (n = 14)	1.02 (0.76 – 1.22)^c	0.73

OR (odds ratio) in a codominant model for the T-allele determined in logistic regression analyses.^(a)Adjusted for sex, age and glycemic status; ^(b)adjusted for sex, age, glycemic status, BMI, blood pressure, dyslipidemia and NAMPT levels; ^(c)adjusted for age and sex. MAF: minor allele frequency. Hardy-Weinberg equilibrium: Brazilian cohort, without CAD (p = 0.49), with CAD (p = 0.91); North-American cohort, without CAD (p = 0.54), with CAD (p = 0.003).

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