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Table 2 Modified LDLs, HDL composition and Lp-PLA2 activity in patients with type 2 diabetes and control subjects

From: Impact of the LDL subfraction phenotype on Lp-PLA2 distribution, LDL modification and HDL composition in type 2 diabetes

 

Type 2 diabetes phenotype A (n = 77)

Type 2 diabetes phenotype B (n = 45)

Control group

ANOVA

(n = 54)

p-value

Modified LDL

Oxidized LDL (U/L)

61.4 ± 20.0

78.6 ± 26.7 a

51.2 ± 19.3 a,b

0.005

Glycated LDL (mg/dL)

2.17 ± 0.94

2.77 ± 1.41 a

1.85 ± 0.73 a,b

0.030

LDL(−) (%)

7.6 ± 3.5

7.7 ± 3.1

6.1 ± 2.0 a,b

0.017

HDL composition

Cholesterol (%)1

17.1 ± 2.3

15.6 ± 3.0 a

17.3 ± 2.3 b

0.204

Trigycerides (%)

4.3 ± 1.7

6.7 ± 1.9 a

3.1 ± 1.0 a,b

<0.001

Phospholipids (%)

33.5 ± 4.3

31.3 ± 3.3 a

32.8 ± 3.7

0.076

apoA-I (%)

31.9 ± 5.8

32.8 ± 6.3

34.3 ± 5.7 a,b

0.193

apoA-II (%)

13.2 ± 3.4

13.6 ± 2.6

12.5 ± 2.9 a,b

0.265

NEFA(mol/mol apoA-I)

1.1 ± 0.6

1.0 ± 0.6

1.0 ± 0.9

0.907

Ratio lipid/protein

1.20 ± 0.28

1.19 ± 0.27

1.16 ± 0.27 a,b

0.539

Ratio A-I/A-II

2.61 ± 0.92

2.54 ± 0.81

2.98 ± 1.12 a,b

0.112

Ratio chol/trigl

4.65 ± 2.19

2.57 ± 0.91

6.32 ± 2.68 a,b

<0.001

PON1 activity

78.5 ± 25.5

82.6 ± 25.5

82.5 ± 23.1

0.152

(μmol/min/mL)

Lp-PLA2 activity(μmol/min/mL)

Total Lp-PLA2

20.1 ± 6.6

23.0 ± 7.2 a

19.1 ± 6.2 b

0.627

HDL-Lp-PLA2

6.8 ± 2.7

7.1 ± 3.5

6.2 ± 2.6

0.995

apoB-associated-Lp-PLA2

13.3 ± 4.8

15.9 ± 4.6 a

12.9 ± 3.3 b

0.539

% HDL-Lp-PLA2

33.9 ± 10.5

30.9 ± 11.4 a

32.4 ± 10.6

0.510

% apoB-associated-Lp-PLA2

66.1 ± 19.4

69.1 ± 21.2 a

67.6 ± 19.8

0.510

  1. a, P < 0.05 vs phenotype A patients; b, P < 0.05 vs phenotype B patients.
  2. 1 Composition is expressed as the percentage of the mass of cholesterol, triglycerides, phospholipids, apoA-I and apoA-II.