Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis

Table 2 Comparison between previously published SNP results and results obtained in this study

SNP	Initially published by	EA	EAF	Hardy-Weinberg equilibrium	Published beta	Published P value	Study beta	Study SE	Study p values	Meta-p value	Effect on outcome P value (SE)	Effect on outcome hazard ratio	Effect on outcome 95% CIs for HR
rs17568359	Vasan et al.	C	0.06	0.35	-4.78	8.53x10^-8	-0.16	0.13	0.23	1.75x10^-6	0.29 (0.10)	0.90	0.73-1.10
rs7565161	Vasan et al.	A	0.44	0.75	-3.01	3.19x10^-7	0.09	0.07	0.19	5.35x10^-6	0.69 (0.06)	0.98	0.87-1.09
rs7910620	Vasan et al.	G	0.01	1.00	0.17	5.62x10^-9	-0.44	0.42	0.29	1.45x10^-8	0.74 (0.58)	0.83	0.27-2.61
rs2059238	Vasan et al.	A	0.23	0.31	-0.02	1.89x10^-7	-0.06	0.07	0.45	5.07x10^-7	0.56 (0.05)	1.03	0.93-1.15
rs17132261	Vasan et al.	T	0.01	1.00	0.06	3.36x10^-7	0.73	0.31	0.02	1.03x10^-8	0.54 (0.20)	1.13	0.76-1.68
rs6797133	Shah et al.	A	0.39	0.66	-3.7	1.2x10^-7	3.73x10^-3	0.06	0.95	2.42x10^-7	0.74 (0.05)	1.02	0.92-1.12
rs2292462	Shah et al.	G	0.45	0.06	-218.6	3.2x10^-9	-0.20	0.06	2.26x10^-3	5.86x10^-10	<0.01 (0.05)	0.87	0.80-0.96
rs4966014	Shah et al.	C	0.31	0.33	-181.8	1.3x10^-7	-0.02	0.07	0.74	3.35x10^-8	0.13 (0.06)	0.92	0.82-1.03
rs2290893	Shah et al.	G	0.64	0.77	-201.4	3.7x10^-8	-1.57x10^-3	0.06	0.98	1.70x10^-7	0.17 (0.05)	0.94	0.85-1.03

EA refers to ‘effect allele’, EAF to ‘effect allele frequency’, SE to ‘standard error’. The outcome referenced in the final 3 columns is a composite outcome referring to time to death or hospital admission due to cardiovascular disease.

ISSN: 1475-2840