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Table 2 Risk factors for IHD and CVA by Cox multivariate models in each age group (IHD, upper; CVA, lower)

From: Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age

n = 4014 Total (n = 4014) <65 years (n = 1267) 65-74 years (n = 1731) ≥75 years (n = 1016)
IHD Adjusted HR 95% CI P Adjusted HR 95% CI P Adjusted HR 95% CI P Adjusted HR 95% CI P
Gender (women vs. men) 1.103 0.972–1.268 0.197 1.044 0.967–1.073 0.456 1.085 0.978–1.210 0.101 1.132 0.992–1.278 0.019*
Age (per 10 years) 1.013 0.972–1.066 0.328 1.022 0.977–1.079 0.229 1.054 1.002–1.106 0.049* 1.005 0.871–1.139 0.682
Duration of Diabetes (months) 0.995 0.988–1.003 0.053 1.001 0.991–1.008 0.582 0.993 0.985–0.999 0.033* 0.992 0.982–0.999 0.023*
HbA1C (per 1%) 1.171 1.001–1.356 0.047* 1.327 1.025–1.686 0.032* 1.219 0.973–1.487 0.083 0.792 0.479–1.059 0.134
FPG (per 10 mg/dl) 1.004 0.997–1.008 0.432 1.005 0.996–1.013 0.355 1.004 0.997–1.009 0.592 0.999 0.987–1.007 0.761
SBP(per 10 mmHg) 1.008 0.995–1.021 0.186 1.030 1.000–1.055 0.035* 1.014 0.994–1.037 0.175 0.986 0.954–1.014 0.331
DBP(per 10 mmHg) 0.995 0.978–1.015 0.618 0.982 0.948–1.024 0.386 0.980 0.950–1.011 0.206 1.027 0.986–1.073 0.202
TG (quartile) 1.005 0.889–1.166 0.555 1.002 0.996–1.006 0.502 1.108 0.997–1.220 0.065 1.001 0.961–1.046 0.454
LDL-C (quartile) 1.318 1.103–1.585 0.023* 1.571 1.128–2.524 0.016* 1.050 0.932–1.176 0.112 1.156 0.998–1.309 0.054
HDL-C (quartile) 0.751 0.611–0.917 0.005** 0.828 0.646–1.017 0.072 0.987 0.966–1.008 0.204 0.629 0.401–0.856 0.001**
Non-HDL-C (quartile) 1.023 0.981–1.072 0.075 1.025 1.001–1.121 0.044* 1.073 0.982–1.161 0.086 0.941 0.791–1.102 0.621
LDL-C/HDL-C (quartile) 1.583 1.298–1.945 0.001** 2.324 1.516–3.795 0.001** 1.359 1.028–1.824 0.021* 1.407 1.015–2.592 0.029*
CVA Adjusted HR 95% CI P Adjusted HR 95% CI P Adjusted HR 95% CI P Adjusted HR 95% CI P
Gender 1.164 0.985–1.296 0.351 1.014 0.897–1.240 0.655 1.208 0.896–1.526 0.112 0.953 0.912–1.012 0.063
Age 1.015 0.986–1.039 0.282 1.002 0.957–1.076 0.754 1.007 0.916–1.166 0.537 1.103 1.002–1.217 0.048*
Duration of Diabetes 0.998 0.992–1.001 0.206 1.003 0.987–1.017 0.709 0.996 0.989–1.001 0.096 0.999 0.991–1.005 0.818
HbA1C 1.001 0.790–1.214 0.128 1.019 0.691–1.401 0.814 0.997 0.855–1.222 0.569 0.928 0.822–1.010 0.059
FPG 1.005 0.995–1.005 0.803 1.003 0.990–1.018 0.741 1.002 0.995–1.008 0.592 0.998 0.986–1.008 0.711
SBP 1.009 0.993–1.024 0.276 1.024 0.988–1.055 0.185 1.015 0.992–1.037 0.206 0.989 0.957–1.018 0.458
DBP 0.998 0.978–1.020 0.846 0.995 0.958–1.046 0.831 0.981 0.948–1.016 0.278 1.024 0.978–1.074 0.317
TG 1.132 0.908–1.302 0.156 1.053 0.658–1.742 0.833 1.253 0.900–1.780 0.184 1.169 0.746–1.853 0.497
LDL-C 1.009 0.912–1.191 0.675 1.005 1.001–1.100 0.047* 1.015 0.892–1.136 0.714 0.997 0.982–1.012 0.631
HDL-C 0.742 0.596–0.901 0.003** 0.715 0.591–1.191 0.200 0.750 0.494–1.000 0.049* 0.536 0.320–0.851 0.007**
Non-HDL-C 0.981 0.945–1.019 0.206 1.021 1.003–1.141 0.045* 0.942 0.872–1.013 0.172 1.012 0.954–1.077 0.226
LDL-C/HDL-C 1.180 0.951–1.477 0.132 1.271 0.819–2.232 0.263 1.114 0.853–1.582 0.356 1.209 0.803–1.847 0.364
  1. The top panels show the analyses of IHD for subjects aged <65 years (left), 65–74 years (middle) and ≥75 years (right). The lower panels show the incidence of CVA. Bold indicate statistically significant factors. Hazard ratios and 95% CIs are shown. The ratio of males to females was 1. As LDL-C/HDL-C interacts strongly with LDL-C and HDL-C, and non-HDL-C interacts triglyceride and LDL-C, analysis of non-HDL-C and LDL-C/HDL-C were separately shown in methods section.