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Table 2 Risk factors for IHD and CVA by Cox multivariate models in each age group (IHD, upper; CVA, lower)

From: Metabolic predictors of ischemic heart disease and cerebrovascular attack in elderly diabetic individuals: difference in risk by age

n = 4014

Total (n = 4014)

<65 years (n = 1267)

65-74 years (n = 1731)

≥75 years (n = 1016)

IHD

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Gender (women vs. men)

1.103

0.972–1.268

0.197

1.044

0.967–1.073

0.456

1.085

0.978–1.210

0.101

1.132

0.992–1.278

0.019*

Age (per 10 years)

1.013

0.972–1.066

0.328

1.022

0.977–1.079

0.229

1.054

1.002–1.106

0.049*

1.005

0.871–1.139

0.682

Duration of Diabetes (months)

0.995

0.988–1.003

0.053

1.001

0.991–1.008

0.582

0.993

0.985–0.999

0.033*

0.992

0.982–0.999

0.023*

HbA1C (per 1%)

1.171

1.001–1.356

0.047*

1.327

1.025–1.686

0.032*

1.219

0.973–1.487

0.083

0.792

0.479–1.059

0.134

FPG (per 10 mg/dl)

1.004

0.997–1.008

0.432

1.005

0.996–1.013

0.355

1.004

0.997–1.009

0.592

0.999

0.987–1.007

0.761

SBP(per 10 mmHg)

1.008

0.995–1.021

0.186

1.030

1.000–1.055

0.035*

1.014

0.994–1.037

0.175

0.986

0.954–1.014

0.331

DBP(per 10 mmHg)

0.995

0.978–1.015

0.618

0.982

0.948–1.024

0.386

0.980

0.950–1.011

0.206

1.027

0.986–1.073

0.202

TG (quartile)

1.005

0.889–1.166

0.555

1.002

0.996–1.006

0.502

1.108

0.997–1.220

0.065

1.001

0.961–1.046

0.454

LDL-C (quartile)

1.318

1.103–1.585

0.023*

1.571

1.128–2.524

0.016*

1.050

0.932–1.176

0.112

1.156

0.998–1.309

0.054

HDL-C (quartile)

0.751

0.611–0.917

0.005**

0.828

0.646–1.017

0.072

0.987

0.966–1.008

0.204

0.629

0.401–0.856

0.001**

Non-HDL-C (quartile)

1.023

0.981–1.072

0.075

1.025

1.001–1.121

0.044*

1.073

0.982–1.161

0.086

0.941

0.791–1.102

0.621

LDL-C/HDL-C (quartile)

1.583

1.298–1.945

0.001**

2.324

1.516–3.795

0.001**

1.359

1.028–1.824

0.021*

1.407

1.015–2.592

0.029*

CVA

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Adjusted HR

95% CI

P

Gender

1.164

0.985–1.296

0.351

1.014

0.897–1.240

0.655

1.208

0.896–1.526

0.112

0.953

0.912–1.012

0.063

Age

1.015

0.986–1.039

0.282

1.002

0.957–1.076

0.754

1.007

0.916–1.166

0.537

1.103

1.002–1.217

0.048*

Duration of Diabetes

0.998

0.992–1.001

0.206

1.003

0.987–1.017

0.709

0.996

0.989–1.001

0.096

0.999

0.991–1.005

0.818

HbA1C

1.001

0.790–1.214

0.128

1.019

0.691–1.401

0.814

0.997

0.855–1.222

0.569

0.928

0.822–1.010

0.059

FPG

1.005

0.995–1.005

0.803

1.003

0.990–1.018

0.741

1.002

0.995–1.008

0.592

0.998

0.986–1.008

0.711

SBP

1.009

0.993–1.024

0.276

1.024

0.988–1.055

0.185

1.015

0.992–1.037

0.206

0.989

0.957–1.018

0.458

DBP

0.998

0.978–1.020

0.846

0.995

0.958–1.046

0.831

0.981

0.948–1.016

0.278

1.024

0.978–1.074

0.317

TG

1.132

0.908–1.302

0.156

1.053

0.658–1.742

0.833

1.253

0.900–1.780

0.184

1.169

0.746–1.853

0.497

LDL-C

1.009

0.912–1.191

0.675

1.005

1.001–1.100

0.047*

1.015

0.892–1.136

0.714

0.997

0.982–1.012

0.631

HDL-C

0.742

0.596–0.901

0.003**

0.715

0.591–1.191

0.200

0.750

0.494–1.000

0.049*

0.536

0.320–0.851

0.007**

Non-HDL-C

0.981

0.945–1.019

0.206

1.021

1.003–1.141

0.045*

0.942

0.872–1.013

0.172

1.012

0.954–1.077

0.226

LDL-C/HDL-C

1.180

0.951–1.477

0.132

1.271

0.819–2.232

0.263

1.114

0.853–1.582

0.356

1.209

0.803–1.847

0.364

  1. The top panels show the analyses of IHD for subjects aged <65 years (left), 65–74 years (middle) and ≥75 years (right). The lower panels show the incidence of CVA. Bold indicate statistically significant factors. Hazard ratios and 95% CIs are shown. The ratio of males to females was 1. As LDL-C/HDL-C interacts strongly with LDL-C and HDL-C, and non-HDL-C interacts triglyceride and LDL-C, analysis of non-HDL-C and LDL-C/HDL-C were separately shown in methods section.