Figure 3
Effect of FABP4 on IRS1 and Akt activation in HUVECs. A, effect on insulin-stimulated IRS1 phosphorylation at Tyr989. B, effect on insulin-stimulated Akt phosphorylation at Ser473. HUVECs were incubated with FABP4 at the indicated concentrations for 30 minutes and then with insulin (600 nM) for 30 minutes. Representative blots are shown. The data are given as the mean ± standard deviation from three independent experiments. *P < 0.05 vs. insulin(−) / FABP4(−); #P < 0.05 vs. insulin(+) / FABP4(−).